Kabanov, A.S., Kosogova, T.A., Shishkina, L.N., Teplyakova, T.V., Skarnovich, M.O., Mazurkova, N.A., Puchkova, L.I., Malkova, E.M., Stavsky, E.A., Drozdov, I.G.

Study of antiviral activity of extracts obtained from basidial fungi against influenza viruses of different subtypes in experiments in vitro and in vivo

State Scientific Center of Virology and Biotechnology «Vector», Koltsovo, Novosibirsk region, Russia

Aim. To study antiviral activity of extracts obtained from basidial fungi against influenza viruses of different subtypes. Materials and methods. Antiviral activity of extracts obtained from basidial fungi against influenza virus A/chicken/Kurgan/05/2005 (H5N1) was determined in in vitro experiments. Changes in infectiousness of pandemic influenza virus A/Moscow/226/2009 (H1N1)v caused by extracts of basidial fungi was studied in experiments in vitro and in vivo. Results. Seventy water extracts of basidial fungi were studied, of which 10 were able to inhibit infectiousness of influenza virus strain A/chicken/Kurgan/05/2005 (H5N1) in MDCK cell culture. Also, several studied extracts decreased infectiousness of pandemic influenza virus strain A/Moscow/226/2009 (H1N1)v in MDCK cells and inhibit its reproduction in lungs of infected mice. Conclusion. High antiviral activity of extracts obtained from basidial fungi against influenza viruses opens perspectives for development of drugs with preventive and treatment effects.
Zh. Mikrobiol. (Moscow), 2011, No. 1, P. 40—43